Melotonin

Melotonin Character

1. Chemical name: n-acetyl-5-methoxytryptamine

2. Molecular formula: C13N2H16O2

3. Molecular weight: 232.27

4. Melting point: 116℃ ~ 118℃

5. HS Code: 29329990

6. CAS no. : 73-31-4

Why Take Melatonin Supplements?

Melatonin is secreted in a circadian rhythm that peaks between 2 and 3 am. The level of melatonin at night directly affects the quality of sleep. With the increase of age, especially after 35 years old, the internal melatonin secretion in the body decreases significantly, by 10-15% on average every 10 years, leading to sleep disorders and a series of functional disorders. The decrease of melatonin level and sleep loss is one of the important signs of human brain aging.

Therefore, supplementation of melatonin from outside the body can maintain the melatonin level in the body in a young state, adjust and restore the circadian rhythm, not only deepen sleep, improve sleep quality, but more importantly, improve the function of the whole body, improve the quality of life, and delay aging.

The Main Action Of Melatonin

• The anti-aging effect of melatonin

Free radicals may be produced during enzymatic and non-enzymatic reactions in the body. Free radicals are closely related to aging. The generation and elimination of free radicals in normal organisms are in a dynamic balance. Once this balance is broken, free radicals will cause the damage of biological macromolecules such as lipids, proteins and nucleic acids, leading to the destruction of cell structure and the aging of organisms. Melatonin protects cell structure by scavenging free radicals, fighting oxidation and inhibiting lipid peroxidation, preventing DNA damage and reducing the amount of peroxide in the body.

• Regulating immune function of melatonin

Maestron found that functional or pharmacological suppression of melatonin biosynthesis led to suppression of humoral and cellular immune effects in mice. Melatonin can antagonize the stress-induced immunosuppressive effect induced by mental factors (acute anxiety) in mice, and prevent paralysis and death caused by acute stress induced by infectious factors (sublethal dose of cerebral myocardial virus). Yan jianjun et al. studied the immune regulation effect of melatonin on H22 liver cancer mice and found that melatonin could improve CD4+CD8+ value of tumor-carrying mice, increase the number of peripheral blood lymphocytes and eosinophils in coordination with il-2, enhance the activity of spleen cells NK and LAK, and promote the induction of il-2. In addition, the regulation effect of melatonin on the function of macrophages in H22 liver cancer mice was also studied. It was found that the killing activity of macrophages and the induced water of il-1 were significantly increased after injection, indicating a selective regulation effect on the function of macrophages. Kethleen et al. (1994) found that melatonin can activate human monocytes, induce cytotoxicity and il-1 secretion.

•The anti-tumor effect of melatonin

Vijayalaxmi et al. (1995) found in vitro study that melatonin had an obvious protective effect on chromosome damage of human peripheral lymphocytes caused by 137Cs gamma-ray (150cGy), and showed a dose-effect relationship. It is antagonistic to the physical and chemical mutagenicity and carcinogenicity of free radicals. In vitro tests showed that melatonin also had a protective effect on the mutagenicity induced by self-made mycin C. Melatonin can reduce the formation of DNA additions induced by chemical carcinogens (safrol) and prevent DNA damage. Melatonin promotes the production of endogenous granulocyte leukocyte/macrophage accumulation factors through bone marrow t-cells, and can be used as an adjuvant therapy for tumors.

Applications Of Melatonin

Whitening and moisturizing cosmetics, hair products, dietary supplements.

Scope of Business

Boherbs Co., Ltd. is a professional manufacturer and wholesaler for herbs & herbal powder (organic certified & conventional standard), plant extract, food ingredients, spices and herbal tea.

We would like to provide raw materials for pharmaceutical factory, scientific research institutions, and health products company and so on.

We are capable to provide One-step solution for contract manufacturing like capsules, teabags, tablets etc. 

Sample orders are available to do the tests.